Start with the drug substance: optimise before you formulate
Solubility challenges can often be addressed early through smart solid-state and API optimisation strategies such as salt selection, polymorph screening, and co-crystal formation.
Taking a drug substance-first approach enables:
Improved
bioavailability
Reduced formulation complexity
Faster, more efficient progression to clinic
API Optimisation & Preformulation
As a critical bridge between drug substance and drug product, preformulation ensures your molecule is fully understood before entering formulation development.
Our approach combines molecular-level insight with bulk property characterisation to enable faster, more informed formulation decisions.
We assess:
- Solubility across temperature and media
- Chemical stability and hygroscopicity
- Drug–excipient compatibility
- Solid-state behaviour, including crystalline and amorphous properties
- Surface and bulk physical characteristics