An Evaluation of the Long-term Impact of Gadolinium-based Contrast Agents on Sensory Nerves in Cynomolgus Monkeys

In this paper published in investigative radiology, a journal of clinical and laboratory research, explore this evaluation of the long-term effects of repeated gadolinium-based contrast agent (GBCA) exposure in cynomolgus monkeys.

GBCAs are used in MRI scans to make internal structures clearer, helping diagnose conditions like infections, cancer, and vascular issues. The study assesses the potential effects of 2 GBCAs on the peripheral nervous system of non-human primates (NHPs) and evaluates their toxicokinetic profile based on the bioanalysis performed at Alnwick. 18 subjects received multiple doses over several months, mirroring human clinical imaging schedules. Researchers then tracked gadolinium retention and potential tissue effects across key organs—including brain, bone, and kidneys. Their findings offer valuable insights into GBCA safety, with implications for monitoring and minimising contrast agent retention in both preclinical and clinical settings.

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